COVID-19 Protocols for Biophysics Labs

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Biophysics protocols (one lab in HG00.800; four labs in the basement A-2.002A, and one EEG lab A-2.002): Phases 2 and 3

Here follows a description of the experimental protocols for the Biophysics researchers who carry out experiments with healthy human participants in Phases 2 (no contact) and 3 (brief contact). The Phase 1 experiments (tests and development of equipment only) are already carried out since May 15, according to the Faculty of Science regulations. The guidelines are written in English because some of the experimenters are foreign.

Note: All existing experimental protocols regarding safety and research integrity for the different experimental setups are applicable also to the COVID-19 protocols. On top of that, the following additional COVID-19 related measures are in place: Anyone who deliberately violates the strict guidelines will be denied further access to the lab spaces until further notice.

For Phase 2 and Phase 3: • Experimental subjects and experimenters are denied access to the department and lab-spaces if they have had any Corona-related symptoms during the two weeks prior to the experiment. They should be entirely symptom-free, and to that effect report this on an informed consent form. A sheet covering relevant triage questions can be found here: https://www.rivm.nl/documenten/triage-klantclient

• Mandatory hygiene instructions are written in the document “Practical Hygiene Guidelines for Experiments with Human Subjects”.

• An experiment can only be planned if there will be sufficient backup for technical support (at least one of the three technicians should be in the building), and for overall safety and medical-assistance backup provided by the BHV. • Only experiments performed by PhD’s, postdocs, and master intern-students (as experimenters) will be allowed, not yet by bachelor interns. Later, if restrictions are more relaxed, we may also add the bachelor interns to this protocol. • Personal contact should be avoided at all times (as in Phase 2 protocol). • Admission to the labs is only allowed during formal office hours. • Anyone entering the lab environment (experimenter and participant) is required to thoroughly wash and disinfect the hands. No gloves (clean hands are considered safer). Soap and alcoholic gel to that effect will be available at all times. • In the laboratory measurement rooms, there is no more than one person during the experiment (typically, the experimental participant). • No studies will be carried out on patients. Experiments will only involve healthy adult volunteers (15-69 years of age). • No more than three of the experimental setups in A-2.002A can be used simultaneously at any given time. Thus, for the four setups, a maximum of 6 people is allowed in the lab space: three experimenters (available: 60 m2 open space) and three subjects for three setups (each ~10 m2 of space). • In the EEG-lab (A-2.002) three people can be maximally present at any one time: two experimenters (in 40 m2), and one participant (in 15 m2 lab). • In the Wing-8 lab-space maximally one experimenter and one participant (in the lab room; 7 m2) are allowed. • Lab reservations should be made through the department’s Google Lab Calendar. An experimental slot has a maximum duration of 2.5 hours, and there should be at least 20 mins between consecutive slots. These 20 mins cannot be used for lengthening an experimental session! • After the experiment, the participant leaves the lab-space as quickly as possible, but the experimenter ensures a thorough clean-up and disinfection of all used materials (including the facial shields) and equipment. He/she indicates the status of the lab with the DIRTY/CLEAN switch (see photos). When a participant enters the lab, the switch must be set to “DIRTY”! • The experimental device to be adjusted, and the table or chair for the participant, are thoroughly disinfected between experiments. • In between experiments the ventilation systems are put on maximum power. During the experiment, the ventilation system is on, to ensure laminar air flow. • On the long tables in the lab-spaces, in front of the setups, experimenters ensure a mutual distance at a minimum of 1.5 m.

• According to Q-portaal from the RadboudUmc, the following guide line is given: “bij een patiënt zonder (verdenking op) COVID-19 en wanneer er sprake is van een handeling waarbij de zorgverlener over langere tijd (> 3 min) zeer dicht (<30 cm) bij het gelaat van de patiënt komt, moet er een chirurgisch masker + spatbril of alleen een face-shield gebruikt worden.”

In Phase 3: • If brief personal contact is unavoidable between experimenter and participant (e.g., to adjust a small device like an eye tracker or wrist- or head-band on the body/head of the subject), it can only be done while the experimenter has fully protected hands, torso, and head: - he/she wears the personal lab-coat (sleeves rolled), - he/she wears the personal facial shield (see below), and - he/she extensive cleaned the hands and lower arms with soap prior to contact. • The experimental device to be adjusted, and the table or chair for the participant, are thoroughly cleaned and disinfected between experiments. • The EEG and fNIRS caps should be cleaned with soap (which is considered the most effective virus-destroyer), and washed thereafter with luke-warm water. No alcohol cleaning of the electrodes.