Difference between revisions of "Good Laboratory Practice (GLP)"
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== Rules == | == Rules == | ||
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* No food or drinks in the labs | * No food or drinks in the labs | ||
* Never leave subjects alone | * Never leave subjects alone | ||
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| + | ==Lab journal== | ||
| + | Standard operating procedure for record keeping in a lab journal | ||
| + | |||
| + | |||
| + | Obtaining and preparing the lab journal | ||
| + | • Everybody who is performing any experimental work has to own and use a lab journal. | ||
| + | • The lab journal can be picked up at the secretariat. | ||
| + | • The cover of the lab journal has to provide the following information: | ||
| + | A) The name of the experimenter (names if lab journal is continued by a successor, see below) | ||
| + | B) The title of the study/project | ||
| + | C) The starting date and eventually the date of finalization of the journal. | ||
| + | • Lab journals which are not filled after a experimenter has finalized the study can be continued by experimenters working on continuation of the project or a similar study. | ||
| + | |||
| + | Record keeping: general instructions | ||
| + | *All pages are numbered before using the lab journal. | ||
| + | *The first 4 pages will be assigned to create a table of content of the main experiments (with page numbers) | ||
| + | *The standard language of the lab journal is English. | ||
| + | *The header of the description of every new experiment shows a title and the date. | ||
| + | *The respective experimental protocol has to be clearly depicted. If you used paper forms then the form has to be transferred or copied and pasted into the lab journal. | ||
| + | *Every single step of the experiment has to be described in a way that an external reader can fully reproduce the experiment. | ||
| + | *If applicable one can refer to the protocols and descriptions of previous experiments in the same lab journal WITH the respective page numbers. | ||
| + | *When referring to previous descriptions or protocols EVERY single modification or exception has to be noted. | ||
| + | *When using solutions with lot-numbers (e.g. enzymes, antibodies, specific chemicals etc.) the lot numbers has to be noted in the lab journal. | ||
| + | *Clearly note how samples are marked and where they are stored. | ||
| + | *All incidences, perceptions, results and conclusions have to be written down in a clear, transparent and reproducible way. | ||
| + | *Also experiments that failed or have been aborted need to be noted down, including a clear explanation of what caused the failure of abortion. | ||
| + | *It is strictly forbidden to remove pages or to take the lab journal home. | ||
| + | |||
| + | Data | ||
| + | *Write down the name and location of all data files that are connected to a given experiment. | ||
| + | |||
| + | Control system | ||
| + | *Every month the direct supervisor will check the lab journal. | ||
| + | *The direct supervisor will place her/his signature underneath the last page that was checked. If needed, shortcomings will be directly discussed with the experimenter. | ||
| + | *Every 3 months, some lab journals will be checked for compliance with these rules by the technical staff. | ||
| + | |||
| + | Storing the lab journal | ||
| + | *Finalized lab journals that are not directly relevant for ongoing studies anymore will be delivered to the CNS secretary and centrally archived. | ||
| + | *At regular intervals but at latest after a experimenter finalized a lab journal, the journal needs to be scanned and electronically stored. One file per lab journal! | ||
| + | |||
== Problem solving == | == Problem solving == | ||
| − | |||
== Issue Tracking == | == Issue Tracking == | ||
Revision as of 11:08, 22 June 2023
Rules
- No internet on experimental PCs
- No food or drinks in the labs
- Never leave subjects alone
Lab journal
Standard operating procedure for record keeping in a lab journal
Obtaining and preparing the lab journal
• Everybody who is performing any experimental work has to own and use a lab journal.
• The lab journal can be picked up at the secretariat.
• The cover of the lab journal has to provide the following information:
A) The name of the experimenter (names if lab journal is continued by a successor, see below)
B) The title of the study/project
C) The starting date and eventually the date of finalization of the journal.
• Lab journals which are not filled after a experimenter has finalized the study can be continued by experimenters working on continuation of the project or a similar study.
Record keeping: general instructions
- All pages are numbered before using the lab journal.
- The first 4 pages will be assigned to create a table of content of the main experiments (with page numbers)
- The standard language of the lab journal is English.
- The header of the description of every new experiment shows a title and the date.
- The respective experimental protocol has to be clearly depicted. If you used paper forms then the form has to be transferred or copied and pasted into the lab journal.
- Every single step of the experiment has to be described in a way that an external reader can fully reproduce the experiment.
- If applicable one can refer to the protocols and descriptions of previous experiments in the same lab journal WITH the respective page numbers.
- When referring to previous descriptions or protocols EVERY single modification or exception has to be noted.
- When using solutions with lot-numbers (e.g. enzymes, antibodies, specific chemicals etc.) the lot numbers has to be noted in the lab journal.
- Clearly note how samples are marked and where they are stored.
- All incidences, perceptions, results and conclusions have to be written down in a clear, transparent and reproducible way.
- Also experiments that failed or have been aborted need to be noted down, including a clear explanation of what caused the failure of abortion.
- It is strictly forbidden to remove pages or to take the lab journal home.
Data
- Write down the name and location of all data files that are connected to a given experiment.
Control system
- Every month the direct supervisor will check the lab journal.
- The direct supervisor will place her/his signature underneath the last page that was checked. If needed, shortcomings will be directly discussed with the experimenter.
- Every 3 months, some lab journals will be checked for compliance with these rules by the technical staff.
Storing the lab journal
- Finalized lab journals that are not directly relevant for ongoing studies anymore will be delivered to the CNS secretary and centrally archived.
- At regular intervals but at latest after a experimenter finalized a lab journal, the journal needs to be scanned and electronically stored. One file per lab journal!
Problem solving
Issue Tracking
Issues are problems that you cannot solve by yourself or problems that you can solve by yourself but are important enough to document. Issues should be documented on gitlab.
See also Issues & Problems